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Expert Opin Biol Ther. Byadults over 60 years of age will constitute Neurological manifestations of EV71 infection 1.

Author information Article notes Copyright and License information Disclaimer. Hence, all patients with suspected EV71 infection should be carefully observed for all clinical symptoms, including myoclonus and ataxia that are the characteristic clinical features of brainstem encephalitis.

Data collection and measurement Each participant completed a standardized questionnaire through a face-to-face interview. This may have led to the misclassification of some of the patients with controlled hypertension as patients with uncontrolled hypertension due to an increase in blood pressure on the day of study.

The male participants were significantly older, were taller and had greater weight, higher waist circumference, lower systolic blood pressure, higher diastolic blood pressure, lower total cholesterol, lower triglycerides, lower high-density lipoprotein-cholesterol, leu low-density lipoprotein-cholesterol and higher MMSE scores than the female participants. J Microbiol Immunol Infect. Uncontrolled hypertensives among hypertensives reference group. Outcome of enterovirus 71 infections with or without stage-based management: Most EV71 cases remain at stage 1, some progress to stage 2, and a few advance to the most severe condition, stage 3.

Clinical manifestations of CNS infections caused by enterovirus type Efficacy, safety, lfi immunogenicity of an enterovirus 71 vaccine in China. Each participant completed a standardized questionnaire through a face-to-face interview.

Vascular risk factors and cognitive disorders. As the most important risk factor for stroke, hypertension substantially increases the risk of cognitive se. Neurological symptoms or signs appear within 3 1999 5 days after the onset of fever or skin lesions Therefore, during EV71 epidemics, the neurological complications of EV71 infection should always be considered in children who develop neurological diseases, even when patients show no skin lesions characteristic of HFMD.


Enterovirus 71 infection and neurological complications

Footnotes Conflicts of interest: Nucl Med Commun ; It is estimated that approximately 0. The enterovirus 71 outbreak in Taiwan: A study using an orally infected EV71 murine model has suggested that EV71 enters the CNS 19999 the active retrograde axonal-transport system This article has been cited by other articles in PMC. Long-term cognitive and motor deficits after enterovirus 71 brainstem encephalitis in children.

The projected effect of risk factor reduction on Alzheimer’s disease prevalence. We suggest that improved diagnoses and optimal therapeutics are needed to achieve the aim of cognitive decline prevention.

Published online Oct Trained observers measured the body height, weight, waist circumference and blood pressure of each participant according to the standardized protocol. Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons. Since EV71 occasionally involves the central nervous system CNS and can causes serious and potentially fatal neurological complications, it has emerged as a major concern among pediatric infectious diseases, particularly in the Asia-Pacific region 12.

The relationship between the prevalence, treatment and control of hypertension and the MMSE score continuous variable was examined using a multivariable linear regression model.

Although the gold standard for the diagnosis of enterovirus infection is virus isolation via viral culture, this takes more than 7—10 days, and nowadays a molecular serotyping approach is usually employed for the virological diagnosis of EV71 using polymerase chain reaction and sequencing of the VP1 gene 2.

For the prevalence of MCI, both male and female participants showed trends that were similar to those of the general population, but the differences were not significant in females. However, it seems to take time for the promotion and approval of these vaccines to take effect in various countries.


In the hypertensive patient population, the rates of hypertension treatment and control were A review on blood pressure and ischaemic white matter lesions. The results demonstrated the high safety and immunogenicity of the EV71 vaccines.

Asymptomatic circulation of HEV71 in Norway. It is worth noting that the two ORs ORs 11999 the prevalence of MCI in treated hypertensive patients compared with all untreated hypertensive patients and in patients with controlled hypertensive compared with those with non-controlled hypertension regardless re treatment obtained throughout the main analyses were similar.

More than 30, infants and children aged 6—71 months from 3 different regions of China were included in those clinical trials 5859 Find articles by Kyung Yeon Lee.

Virological diagnosis of enterovirus type 71 infections: Cochrane Database Syst Rev ; Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment. Ina major epidemic of EV71 in Taiwan caused 1. Blood pressure and treatment of persons with hypertension as it relates to cognitive outcomes including executive function.

Overall, the prevalence of MCI was higher in hypertensive EV71 infection causes hand, foot and mouth disease HFMD in children, and usually resolves spontaneously. In Korea, epidemics of EV71 infection 199 between and and included fatal cases. Please review our privacy policy. Expert Rev Anti Infect Ther.

Enterovirus 71 infection and neurological complications

Although we have adjusted the potential confounding variables in the analysis, other undetected covariates might affect the results of the current study. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas.

The peak seasons for the disease are late spring to summer, although infections occur with high incidence throughout the year in tropical areas.

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